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FAQ: Long-term Melatonin Use and Heart Health Risks
TL;DR
Long-term melatonin users gain awareness of potential heart risks, allowing them to seek safer sleep alternatives and maintain better cardiovascular health.
Researchers analyzed five years of health records from 130,828 insomnia patients, finding melatonin users had 90% higher heart failure risk and doubled mortality rates.
This research promotes public health by identifying potential risks of widely-used supplements, encouraging safer sleep solutions for better community wellbeing.
A surprising study reveals long-term melatonin use may increase heart failure risk by 90%, challenging assumptions about this popular sleep supplement.
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The study found that adults with insomnia who used melatonin supplements for at least one year were more likely to be diagnosed with heart failure, require hospitalization for heart failure, or die from any cause compared to those who never used melatonin.
Researchers reviewed 5 years of health records for more than 130,000 adults with insomnia who had used melatonin for at least a year.
No, the study found an association between melatonin use and increased risk of heart failure or death, but it cannot prove a cause-and-effect relationship.
Melatonin is a hormone naturally produced by the pineal gland that helps regulate the sleep-wake cycle, and synthetic versions are commonly used to treat insomnia and jet lag as over-the-counter supplements.
Long-term use was defined as using melatonin for a year or more, as documented in electronic health records.
This preliminary study is scheduled to be presented at the American Heart Association's Scientific Sessions 2025, which takes place November 7-10, 2025, in New Orleans.
In the U.S., over-the-counter melatonin supplements are not regulated, so each brand can vary in strength, purity, and other characteristics.
This research raises safety concerns about melatonin supplements, which are widely promoted as safe sleep aids but lack data demonstrating their long-term cardiovascular safety.
People should be aware that this preliminary research suggests potential cardiovascular risks with long-term melatonin use, and they should discuss sleep aid options with their healthcare providers.
The findings are considered preliminary since they come from a research abstract presented at a scientific meeting and have not yet been peer-reviewed or published as a full manuscript in a scientific journal.
Curated from NewMediaWire
