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FAQ: Assessing Stroke Risk in Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
TL;DR
A new risk assessment tool helps identify ATTR-CM patients at highest stroke risk, enabling targeted preventive treatments for better clinical outcomes.
Researchers developed a noninvasive echocardiogram tool measuring atrial contraction function to predict stroke risk in transthyretin amyloid cardiomyopathy patients.
This research advances stroke prevention for heart disease patients, potentially saving lives and reducing disability through early risk identification.
A hidden heart pumping glitch triples stroke risk in certain patients, revealed by a novel assessment method from UK researchers.
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ATTR-CM is a progressive condition where misshapen transthyretin protein accumulates in the heart, stiffening heart walls and making it difficult for the left ventricle to relax and fill with blood, which can raise stroke risk even with normal heart rhythm.
People with ATTR-CM who have atrial electromechanical dissociation (AEMD) - where the atrium looks normal on ECG but doesn't contract effectively - were more than 3 times as likely to experience stroke or transient ischemic attack compared to those with normal atrial contraction.
It identifies a hidden atrial dysfunction that increases stroke risk in ATTR-CM patients, suggesting atrial contraction matters as much as heart rhythm in predicting risk, which could guide earlier conversations about preventive strategies including anticoagulation medications.
AEMD is a condition where the upper heart chamber (atrium) looks normal on an electrocardiogram but does not contract and pump blood effectively, affecting about 1 in 8 ATTR-CM patients with regular heart rhythm.
Researchers at the U.K. National Amyloidosis Centre analyzed health records between 2003 and 2023, reviewing more than 2,300 adults with transthyretin amyloid cardiomyopathy during nearly three years of follow-up.
A noninvasive risk assessment tool may help identify ATTR-CM patients at high stroke risk who might benefit from preventive measures, addressing the current lack of tools to identify those at highest risk for stroke from this condition.
The preliminary study will be presented at the American Heart Association's Scientific Sessions 2025, held November 7-10 in New Orleans.
Even with regular heart rhythm, some ATTR-CM patients may still be at stroke risk if their atrium doesn't squeeze well, and this hidden dysfunction could help guide earlier conversations about preventive treatment strategies.
The study is a research abstract presented at a scientific meeting and is not yet peer-reviewed; the findings are considered preliminary until published as full manuscripts in a peer-reviewed scientific journal.
Curated from NewMediaWire
