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FAQ: Enantioselective Maternal Transfer of Pesticide Metabolite and Thyroid Effects
TL;DR
Companies can gain regulatory advantage by developing pesticides that minimize the S-enantiomer form, reducing multigenerational toxicity and environmental liability.
The study used zebrafish feeding trials and molecular docking simulations to show S-o,p'-DDD accumulates 134-176% more in adults and transfers efficiently to offspring causing developmental defects.
This research helps create safer environmental standards by revealing how pesticide metabolites harm future generations, protecting wildlife and ecosystem health long-term.
A mirror-image pesticide molecule caused dramatically different effects in fish offspring, with one form binding more strongly to thyroid proteins and creating severe developmental issues.
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This research investigates how two mirror-image forms (enantiomers) of the pesticide metabolite o,p'-DDD behave differently when transferred from mother zebrafish to their offspring, and how this affects development and thyroid function across generations.
The study shows that ignoring the differences between enantiomers can lead to underestimating environmental risks, as the S-enantiomer caused more severe effects despite being chemically similar to the R-enantiomer.
Researchers fed adult zebrafish diets containing each form of o,p'-DDD for four weeks, then measured chemical accumulation in adults and embryos, tracked hatching success, deformities, survival, and thyroid hormone changes, and used computer modeling to study protein interactions.
The S-enantiomer accumulated 134-176% more in adults and over 100% more in larvae than the R-enantiomer, leading to increased mortality, malformations, and reduced hatching success in offspring exposed to S-DDD.
Offspring consistently carried higher chemical levels than their parents, showing that maternal transfer was highly efficient, with the S-enantiomer transferring more effectively than the R-enantiomer.
Molecular docking simulations showed that S-DDD binds more strongly to several key proteins involved in producing and regulating thyroid hormones, explaining its greater biological impact.
The research was led by Lili Niu and published in Environmental Chemistry and Ecotoxicology, with funding from the National Natural Science Foundation of China and Zhejiang Province.
These findings suggest that environmental risk assessments should consider enantiomer-specific effects to improve ecological risk predictions and develop more accurate environmental standards for long-lasting pollutants.
The original paper is available with DOI: 10.1016/j.enceco.2025.10.021 and URL: https://doi.org/10.1016/j.enceco.2025.10.021
They should recognize that even small structural differences in chiral pesticide metabolites can lead to large differences in accumulation, hormone disruption, and developmental effects across generations, meaning racemic mixture assessments may underestimate real-world hazards.
Curated from 24-7 Press Release
