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FAQ: Creative Biolabs' Enhanced mRNA Platform for Therapeutics and iPSC Reprogramming
TL;DR
Creative Biolabs' integrated mRNA platform offers researchers a competitive edge by accelerating therapeutic development from design to validation with enhanced efficiency.
The platform uses computational modeling for mRNA structure prediction and custom polymer development to optimize stability and cellular uptake through systematic parameter adjustments.
This technology advances regenerative medicine and safer cell therapies, potentially treating diseases more effectively while reducing genomic integration risks for patients.
Creative Biolabs now uses mRNA to reprogram stem cells without viral vectors, creating safer iPSCs for groundbreaking medical applications.
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Creative Biolabs has upgraded its mRNA technology platform to offer an integrated, end-to-end solution that spans design, delivery, and functional validation for mRNA therapeutics and iPSC reprogramming.
The platform includes in silico mRNA structural prediction for optimizing mRNA constructs, customized polymer (polyplex) development for enhanced delivery, and mRNA-based iPSC reprogramming services that are non-integrative and footprint-free.
The in silico mRNA structural prediction capability uses computational modeling, dynamic programming algorithms, and nearest-neighbor free-energy rules to analyze mRNA secondary structures and three-dimensional conformations, supporting sequence alignment, conserved structure identification, and primer design.
Customized polymer (polyplex) development involves complexing cationic polymers like polyethyleneimine (PEI) with mRNA to create nanoscale polyplexes with enhanced stability and high cellular uptake efficiency, improving mRNA stability in vivo and promoting efficient intracellular release.
The mRNA-based iPSC reprogramming service uses repeated transfection of mRNA expressing reprogramming factors (OCT4, SOX2, KLF4, and GLIS1) to generate induced pluripotent stem cells with high efficiency while eliminating genomic integration risks associated with viral vectors.
The mRNA approach is non-integrative and footprint-free, eliminating genomic integration risks associated with viral vectors while being safe, highly scalable, and supporting cell quantities ranging from millions to billions.
The platform supports pharmaceutical companies, biotechnology firms, and academic programs worldwide working in gene therapy, cancer vaccines, regenerative medicine, and cell therapy applications.
Integrating structure-level design, optimized polymeric delivery, and mRNA-driven cell reprogramming provides clients with a unified and streamlined mRNA development pathway, accelerating projects from early construct optimization to functional demonstration.
Creative Biolabs announced this major upgrade to its mRNA technology platform on November 21, 2025.
Curated from 24-7 Press Release
