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FAQ: Creative Diagnostics' Expanded Hepatic Metabolism Products for Drug Development
TL;DR
Creative Diagnostics' expanded hepatic metabolism products give pharmaceutical researchers a competitive edge by enabling more precise drug testing across multiple species to reduce clinical failure risks.
Creative Diagnostics now offers liver-specific fractions including Cytosol, Microsomes, and S9 Fractions from various species to support systematic in vitro metabolism studies for drug development.
These liver metabolism products help researchers develop safer medications by better understanding drug toxicity, potentially reducing harmful side effects and improving patient outcomes worldwide.
The liver generates both therapeutic and toxic metabolites, like ifosfamide producing an antitumor compound alongside nephrotoxic chloroacetaldehyde, highlighting complex organ interactions in drug metabolism.
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Creative Diagnostics has announced the expansion of its comprehensive range of Products for Hepatic Metabolism, including a new line of liver-specific fractions such as Liver Cytosol, Liver Microsomes, and Liver S9 Fractions from various species.
The liver is the primary organ for drug metabolism and the main site of drug-induced toxicity, accounting for over 50% of acute liver failure cases that lead to medication withdrawal or restricted use.
The liver's primary metabolic functions fall into four categories: carbohydrate metabolism, lipid and fatty acid metabolism, protein and amino acid metabolism, and drug metabolism.
The product line includes liver products from humans, non-human primates (macaques and rhesus monkeys), dogs, rats, rabbits, and minipigs.
The core products include Liver Cytosol, Liver Microsomes, and Liver S9 Fractions.
Metabolites generated in the liver circulate to other organs and can cause unintended toxic side effects, as demonstrated by ifosfamide which produces both antitumor and nephrotoxic metabolites.
It enables researchers to study hepatic metabolic processes with high precision and reproducibility, helping bridge the gap between in vitro testing and in vivo outcomes to reduce clinical failure risks.
Researchers can visit the Creative Diagnostics website at https://qbd.creative-diagnostics.com/products-for-hepatic-metabolism.html to learn more about the full catalog.
Creative Diagnostics is a global leader in developing and manufacturing innovative tools and reagents for bioprocess impurity analysis, with a comprehensive portfolio of solutions for biologics quality control.
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