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FAQ: Creative Biolabs' Liposomal Delivery Services and the 'Last-Mile Problem'
TL;DR
Creative Biolabs expands liposomal formulation services, offering companies a competitive edge by improving drug solubility and targeting for oncology and CNS therapeutics.
Creative Biolabs develops liposomal formulations using passive and active loading methods, optimizing encapsulation efficiency through phospholipid composition and buffer concentration adjustments.
Creative Biolabs' liposomal services enhance drug delivery, potentially improving treatment outcomes for patients by enabling safer, more effective therapies for diseases like cancer.
Liposomes can encapsulate everything from small molecules to vaccine adjuvants, creating customizable delivery systems that shape immune responses with precision.
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Creative Biolabs is expanding its liposomal formulation and encapsulation services to tackle the 'last-mile problem' in drug delivery, specifically addressing challenges in lipid selection and encapsulation efficiency.
Liposomes are considered the most successful drug delivery system to date because they effectively solve problems like low drug solubility, stability in serum, circulation half-life, biodistribution, and target tissue selectivity.
The two common obstacles are that it's not straightforward to select appropriate lipids, and it's not easy to obtain sufficient encapsulation efficiency without negatively affecting stability.
Creative Biolabs offers three main services: Liposomal Formulations for Proteins and Peptides, Encapsulation Strategies for Small-Molecule Drugs, and Liposome-Based Adjuvants for Modern Vaccines.
They focus on studying the relationship between encapsulation efficiency and phospholipid composition, buffer concentration, incubation time, incubation temperature, and drug loading to provide optimal formulations.
Liposomal encapsulation improves solubility, reduces systemic exposure, and fine-tunes biodistribution, which is particularly valuable for oncology and CNS drugs that are often hydrophobic, dose-limited by toxicity, or unable to accumulate in the right tissues.
They employ two principal methods: passive loading and active loading, each suited to specific types of compounds and applications.
Liposomal adjuvants allow developers to integrate immunostimulants like MPLA, QS-21, or TLR agonists into customizable lipid structures that can shape immune responses with greater precision.
They provide formulation safety evaluation services that rigorously examine biocompatibility and potential cytotoxicity to ensure formulations meet the highest standards for research use.
You can visit their lipid-based delivery page at https://www.creative-biolabs.com/lipid-based-delivery/ for more information.
Curated from 24-7 Press Release
