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FAQ: Implantable Ultrasound Device for Continuous Blood Pressure Monitoring
TL;DR
This implantable ultrasound device from UC Berkeley researchers offers continuous, precise blood pressure monitoring without motion interference, giving patients and doctors a significant advantage in managing hypertension.
The subcutaneous PMUT array measures arterial diameter changes via ultrasound time-of-flight, converting them to blood pressure values through vessel stiffness models with minimal calibration error.
This technology enables continuous, comfortable blood pressure monitoring, potentially reducing cardiovascular events and improving long-term hypertension management for better global health outcomes.
Researchers implanted a tiny ultrasound device in a sheep that accurately tracked blood pressure by detecting arterial wall movements through tissue.
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The research demonstrates a minimally invasive, subcutaneously implanted ultrasonic device that captures real-time arterial diameter changes to derive precise blood pressure values for continuous monitoring.
Hypertension is a leading cause of heart disease, stroke, and premature mortality, and continuous blood pressure monitoring can significantly reduce cardiovascular risks, but current methods have limitations this device addresses.
The device uses a piezoelectric micromachined ultrasonic transducers (PMUTs) array to measure time-of-flight between ultrasound echoes reflected from arterial walls, converting this into real-time diameter waveforms that correlate with blood pressure through vessel stiffness models.
Researchers from the University of California, Berkeley, and collaborating institutions conducted the study, which was published in Microsystems & Nanoengineering on November 6, 2025.
The research was published on November 6, 2025, and included in vivo testing where the device was implanted in an adult sheep, demonstrating successful performance.
During in vivo testing, researchers implanted the PMUT system above the femoral artery of an adult sheep, where it matched gold-standard arterial line measurements within −1.2 ± 2.1 mmHg (systolic) and −2.9 ± 1.4 mmHg (diastolic).
Unlike conventional cuffs that disrupt daily activity, photoplethysmography (PPG) with shallow penetration, or wearable ultrasound patches sensitive to misalignment, this implanted design avoids motion interference, maintains stable coupling, and provides accurate long-term performance.
The system uses a dense 37 × 45 PMUT array with 29-µm diaphragms operating at approximately 6.5 MHz, featuring a dual-electrode bimorph design for enhanced acoustic output and optimized deep reactive ion etching (DRIE) for structural uniformity.
This technology enables reliable, continuous blood pressure monitoring without the drawbacks of cuffs or fragile wearables, potentially improving cardiovascular disease prevention through more comfortable and accurate tracking.
The full paper is published in Microsystems & Nanoengineering with DOI: 10.1038/s41378-025-01019-w.
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