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FAQ: Lionheart Health's Bioelectric-Enhanced Klotho Nanoflowers for Aging Reversal
The newly filed patent protects a transformative therapeutic system that combines nanoflower-format nanoparticles, bioelectric signaling sequences, and Klotho-modulating biologics to target the cellular and mitochondrial drivers of aging.
TL;DR
Lionheart Health's new patent for bioelectric-enhanced Klotho nanoflowers offers a competitive edge in longevity biotech by targeting cellular aging reversal for healthspan extension.
The platform combines engineered nanoflowers with bioelectric stimulation to upregulate Klotho protein, restore mitochondrial function, and deliver targeted bioactive agents through precise activation sequences.
This technology aims to improve global healthspan by reversing biological aging at the cellular level, potentially reducing age-related diseases and enhancing quality of life.
Flower-shaped nanoparticles activated by bioelectric signals can deliver genetic payloads to mitochondria, offering a novel approach to combat aging through combined nanomedicine and bioelectric therapy.
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The patent covers a therapeutic system called Bioelectric-Enhanced Klotho Nanoflowers that combines nanoflower-format nanoparticles, bioelectric signaling sequences, and Klotho-modulating biologics to target cellular and mitochondrial drivers of aging for aging reversal and healthspan extension.
The system integrates three main components: engineered 'nanoflowers' (flower-shaped hybrid nanoparticles), proprietary bioelectric stimulation sequences, and Klotho-modulating biologics including advanced Klotho-based peptides and gene-expression tools.
The nanoflowers are engineered to upregulate Klotho protein, restore mitochondrial function, deliver targeted bioactive agents, act as nanozyme catalysts to reduce oxidative stress, and enhance regenerative signaling when activated by precise bioelectric patterns.
Bioelectric stimulation increases cellular uptake of nanoflowers, improves intracellular transport, activates the nanoflower's payloads, opens ion channels, directs nanoflowers toward mitochondria, and triggers therapeutic payload release.
Klotho is a longevity-associated protein shown to improve brain, kidney, cardiovascular, and metabolic health. Its expression increases through nanoflower-delivered payloads and bioelectric activation of promoter and epigenetic pathways.
Nanoflowers require bioelectric activation for optimal performance, and bioelectric stimulation is designed to operate in the presence of nanoflowers. Neither component alone can produce the full Klotho-enhancing effect, demonstrating a combined therapeutic benefit.
Howard J. Leonhardt, Founder, Lead Inventor and CEO of Lionheart Health, developed this technology with the goal of creating a system that reverses biological age at the cellular level and enhances healthspan safely, non-invasively, and affordably.
The invention integrates several proprietary Lionheart technologies including BodStim™, BrainBand™, HairCell™, ErectiStim™, Second Brain™, InStim™, EyeCell™, EarCell™, BioLeonhardt™, KidneyCell™, LiverCell™, RegenaLung™, PacreaCell™, TestiStim™, and advanced Klotho-based peptides and gene-expression tools.
The patent was announced on Monday, December 15, 2025, at 7:00 AM Pacific time from Huntington Beach, California.
Curated from Newsworthy.ai
