FAQ on EnPlusOne Biosciences and the Future of RNA Therapeutics

What is EnPlusOne Biosciences’ mission?

EnPlusOne Biosciences aims to enable the synthesis of pure and precise RNA for therapeutic use at limitless scale, addressing the current limitations in RNA manufacturing.

Why is EnPlusOne’s mission important?

The RNA therapeutics market is expanding rapidly, but current manufacturing methods cannot meet the demand for scale and purity, especially for complex RNA types like siRNA and gRNA, making EnPlusOne’s enzymatic approach crucial.

What challenges does current RNA manufacturing face?

Current phosphoramidite chemistry is unsustainable, requires nonrenewable resources, and cannot produce certain RNA types at needed purity or scale, posing environmental and therapeutic limitations.

How does EnPlusOne’s technology differ from current methods?

EnPlusOne uses enzymatic synthesis, mimicking nature’s process, to produce RNA with higher purity and scalability in an environmentally friendly manner, unlike the harsh conditions of phosphoramidite chemistry.

What are the potential benefits of enzymatic RNA synthesis?

Enzymatic synthesis offers scalable, pure, and sustainable RNA production, enabling broader access to RNA therapeutics and opening new avenues for RNA-based drug discovery.

Who is Clare Murray Ph.D.?

Clare Murray Ph.D. is the CEO of EnPlusOne Biosciences, with a background in synthetic organic chemistry and extensive experience in biotechnology, including co-founding Life Edit Therapeutics.

What is the ezRNA platform?

The ezRNA platform is EnPlusOne’s proprietary technology that leverages enzymatic synthesis to produce RNA with unmatched purity and scale, addressing the needs of genetic medicine developers.

How does EnPlusOne’s work impact the future of RNA therapeutics?

By solving the scalability and purity issues of RNA manufacturing, EnPlusOne’s technology could accelerate the development and accessibility of RNA therapeutics for a wide range of diseases.

Where is EnPlusOne Biosciences based?

EnPlusOne Biosciences is based in Watertown, MA, focusing on harnessing the power of enzymes for RNA synthesis.

What educational background does Dr. Murray have?

Dr. Murray holds a B.Sc. in Chemistry and a Ph.D. in Synthetic Organic Chemistry from the University of Liverpool, and an MBA from Duke University’s Fuqua School of Business.